Although we previously showed that AKT-2 plays a protective role in the aorta and identified decreased AKT-2 protein levels in sporadic aortic aneurysm tissue [39], in the present study we found no differential expression of AKT1 or AKT2 in SMCs or fibroblasts in MFS compared to controls. Here, AKT1 is linked to aortic aneurysm.