Moreover, some of the genes identified in ALS patients are also causative for other neurodegenerative disorders, such as C9orf72 and TARDBP for frontotemporal dementia (FTD) and Parkinson’s disease, and SPG7 and SPG11 for hereditary spastic paraplegia, indicating shared pathomechanisms [4,5,6,7]. Here, SPG11 is linked to frontotemporal dementia.