DHTKD1 and amyotrophic lateral sclerosis: Whole-exome and targeted sequencing revealed four additional DHTKD1 variants, i.e., c.209C>G p.(Ala70Gly), c.593T>C p.(Met198Thr), c.628G>T p.(Ala210Ser), and c.2185G>A p.(Gly729Arg), in eight of 198 further ALS patients (Table 1).