However, when grouping the ALS subtypes PMA and LMN-dominant ALS together, DHTKD1 variant carriers more frequently belonged to this grouped subtype with lower motor neuron involvement (2/10, 20% versus 8/215, 3.72% in non-carriers, p = 0.066, two-sided Fisher’s exact test), although the difference was not statistically significant. This evidence concerns the gene DHTKD1 and amyotrophic lateral sclerosis.