LRP4 and Cenani-Lenz syndrome: In addition to the aforementioned variants in the third β-propeller domain, genetic variation spread across other regions of LRP4 is shown to cause other disorders (Figure 1), such as Cenani–Lenz syndactyly syndrome (OMIM #212780), myasthenia gravis (OMIM #616304), and isolated syndactyly [15,19,20].