The RIPK1-MLKL pathway has repeatedly been shown to play a role in atherosclerosis [12], including RIPK1 studies showing its role in macrophage necroptosis in mouse atherosclerosis, its high expression in early human lesions, and that its knockdown leads to reduced atherosclerotic lesions and inflammatory cytokines in mice [13,14]. The gene discussed is MLKL; the disease is atherosclerosis.