The NTSC includes the full complement of presynaptic neurexins (NRXN1-3) and their postsynaptic ligands the neuroligins (NLGN1-3), cerebellin precursors (CBLNs with their GRID1 complexes) and leucine-rich repeat transmembrane proteins (LRRTMs), all of which have been implicated in TS and ASD through multiple associations (Figure 1) [7]. The gene discussed is CBLN1; the disease is Timothy syndrome.