In support of our findings, several ovarian cancer cell lines such as OVCAR-3, -4, -5 and SKOV3 and high grade serous ovarian carcinoma (HGSOC) tissue were found to have greater expression of mRNA and protein of APLNR and its ligand apelin as compared to normal ovarian surface epithelium [48]. Here, APLNR is linked to ovarian serous carcinoma.