These histone changes were related to an increase in the expression of offspring genes, including glutamic pyruvic transaminase 2 (GPT2, which is essential in the maintenance of obesity in the postnatal period) and retinol dehydrogenase 12 (Rdh12 regulates feeding behaviour and adaptation to circadian rhythms). The gene discussed is RDH12; the disease is obesity due to melanocortin 4 receptor deficiency.