Interestingly, another maternal over-feeding model, with Wistar rats fed an HFD (34% fat) during gestation and lactation, described changes in the gene expression and hypermethylation pattern of the insulin receptor (InsR) DNA promoter in the hypothalamus in a sex-specific manner, leading to a metabolic syndrome-like phenotype in the male offspring; however, lower methylation levels of Pomc were associated with weight loss [46]. This evidence concerns the gene INSR and metabolic syndrome.