In a further maternal mouse LPD model, the modification of histone acetylation and increased H3K9 methylation in the promoter domain of the cholesterol 7α-hydroxylase gene (Cyp7a1), which catabolizes the conversion of cholesterol to bile acids, was associated with decreased expression in the liver of male offspring [105]. Here, CYP7A1 is linked to disseminated peritoneal leiomyomatosis.