SOAT1 and Alzheimer disease: As group-wise specific features, we report neuroinflammation related Semaphorin-plexin and JAK/STAT signaling instantiations in A20 group (Figure 11), and wnt cascade being robustly manifested in part of AD group (Figure 8), possibly linked to synaptic plasticity restoration including dendritic spines and axon projections architecture lost upon endogenous opioid exposure [21].