In this study, through functional annotation and gene pathway aggregation analysis, we found that genes associated with periodontitis were also highly expressed in the heart; among them, OPA1-related pathways concern glucose/energy metabolism; ADCY3 takes part in regulating insulin levels and body fat amassing in response to a high-fat diet, and the related disease is the body mass index quantitative trait; the pathways related to NPEPPS cover Class I MHC-mediated antigen processing and presentation, as well as the innate immune system; and ALK is involved in resistance to weight gain. Here, INS is linked to periodontitis.