Thus, it is noteworthy that mutations in SMC complexes are implicated in human diseases, e.g., mutations in the cohesin complex subunits can lead to Cornelia syndrome or mutations in the Nse3 subunit of Smc5/6 causes the lung disease chromosome breakage immunodeficiency syndrome (LICS) [121,122]. Here, NSMCE3 is linked to lung disease, immunodeficiency, and chromosome breakage syndrome;.