In addition to progressive HCM, she finally developed pulmonary hypertension, a clinical feature described in several patients with the p.Ser257Leu amino acid substitution in RAF1 [24] and hydrocephalus, also already reported in association with this variant [24], in this case likely related to intraventricular hemorrhage of prematurity. This evidence concerns the gene RAF1 and Intraventricular hemorrhage.