TFF3 and Barrett esophagus: Our group has developed a the Cytopsonge-TFF3 test, which is a non-endoscopic, pan-oesophageal collection device that is coupled with pathological assessment and immunohistochemical staining for protein TFF3 to identify pathognomonic goblet cells.7, 8, 9, 10 We have recently shown that an offer of the Cytosponge-TFF3 test in primary care increases the detection rate for BE by 10-fold (10.6, 95% CI: 6.0–18.8, p = 0.0004) when compared to standard of care.11