The histopathological diagnosis also confirmed leukoplakia on the dorsal tongue and local early invasive tongue SCC in the 4NQO group (Figure 1H); FISH staining showed that IFITM4P in the 4NQO group was stronger, while mice in the PBS group were not stained (Figure 1H). The gene discussed is IFITM4P; the disease is tongue squamous cell carcinoma.