PRTN3 and rheumatoid arthritis: Additionally, they found that the LtxA-induced citrullinome overlapped with over 44 of the 86 proteins in the RA citrullinome, indicating that Aa-mediated neutrophil hypercitrullination in periodontitis may play a significant role in contributing to the autoantigens in ACPA-positive RA even though it may not be the sole inducer.