Our previous microarray analysis on lineage-labeled AT2 cells isolated from SftpcCreERT2; Rosa26mTmG mouse lungs showed high expression of genes associated with chromatin organization, histone modification, TCA cycle, mitochondrial inner membrane, and a 2.3-fold increase in Micu1 expression at day 8 after SpT4 infection, the period when AT2 cells differentiate into AT1 cells (Supplemental Figure 2D) (31). Here, SUPT4H1 is linked to infection.