Consistent with previous report that both tumour growth and invasion depends on the JNK signalling,17 expression of the JNK phosphatase Puckered (Puc), included as a positive control, blocked RasV12/lgl−/−‐induced tumour growth and invasive metastasis (Figure 1E, E’, O), while knockdown of Toll‐7 alone showed no obvious effect (Figure 1F, G, F’, G’). Here, MAPK8 is linked to neoplasm.