In this study, we first found that the apelin to NT-proBNP ratio < 0.82 × 10−2 units had independent from other biomarkers, such as LAVI, E/e’, LV hypertrophy and hs-TrT, discriminant potency for HFpEF in T2DM patients’ population. Here, NPPB is linked to type 2 diabetes mellitus.