Indeed, NPs, such as N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and BNP, along with high-sensitive cardiac troponins (hs-cTn) remain the dominant predictors of all-cause and CV mortality for patients with HFrEF/HFmrEF, but their importance in predicting events among HFpEF individuals especially having T2DM has not been extensively elucidated and continue to consider as non-optimal [9,10]. Here, NPPB is linked to type 2 diabetes mellitus.