Unadjusted univariate logistic regression showed that apelin to NT-proBNP ratio (OR = 1.32; p = 0.001), LV hypertrophy (OR = 1.16; p = 0.046), age (OR = 1.03; p = 0.048), NT-proBNP > 458 pmol/mL (OR = 1.24; p = 0.001), apelin > 4.5 ng/mL (OR = 1.06; p = 0.046), LAVI > 34 mL/m2 (OR = 1.20; p = 0.001) and E/e’ > 11 (OR = 1.12; p = 0.001) were found to be independent predictors for HFpEF in T2DM patients (Table 3). This evidence concerns the gene APLN and type 2 diabetes mellitus.