In T2DM patients with established HFpEF HOMA-IR demonstrated positive correlation with LH hypertrophy (r = 0.48; p = 0.001), BMI (r = 0.41; p = 0.001), LAVI (r = 0.36; p = 0.001), serum levels of TG (r = 0.37; p = 0.012), NT-proBNP (r = 0.46; p = 0.001), hs-TrT (r = 0.29; p = 0.032) and hs-CRP (r = 0.41; p = 0.014). The gene discussed is CRP; the disease is type 2 diabetes mellitus.