NPPB and Hyponatremia: Therefore, we suggested that this ratio may be useful for T2DM patients receiving optimal pharmacological therapy and probably continuous monitoring for this ratio during point-of-care therapy of T2DM and HFpEF could have practical utility, especially for patients with HFpEF accompanied with hyponatremia and having lower levels of NT-proBNP, but this assumption requires being confirmed in the future.