With advancing knowledge on the role of RAS in the pathogenesis of the new coronavirus disease 2019 (COVID-19), academic literature recognized that, while it has been coopted as the entry point for the SARS-CoV-2 virus on host cells, the ACE2 enzyme also modulates the balance between vasoconstrictors and vasodilators within the heart and kidney, and it plays a significant role in regulating cardiovascular and renal functions [2,3,4]. Here, ACE2 is linked to COVID-19.