FBN1 and Marfan syndrome: In contrast to pathogenic coding variants leading to connective tissue diseases, such as Marfan syndrome (FBN1 gene), Ehlers–Danlos syndrome (collagen-encoding genes) or Loeys–Dietz syndrome (TGF-β receptor-encoding genes) [3], genetic single-nucleotide variations in the interaction with environmental risk factors or other genetic modifiers may increase the risk for STBAD and affect the clinical outcome of patients.