Recently Nystoriak et al. demonstrated that AKAP5 (referred to as AKAP150 in rodents and AKAP79 in humans) anchored to PKA phosphorylates α1C in Ser1928 of L-Type VOCC, inducing vasoconstriction in diabetes and in response to increased levels of extracellular glucose [227]. This evidence concerns the gene AKAP5 and diabetes mellitus.