PRKAG2 and Noonan syndrome: Of note, WES analysis also allowed to reclassify two apparently isolated CM that turned out to be complex ones (one Noonan syndrome, OMIM #163950, and one Pompe disease, OMIM #232300), and one suspected syndromic form that was actually a lethal cardiac glycogen storage disease (OMIM #261740), caused by a de novo variant in PRKAG2 gene.