Hereditary leiomyomatosis and renal cell cancer (HLRCC) are the autosomal dominant disorder caused by germline mutations in fumarate hydratase (FH), which is characterized by multiple cutaneous piloleiomyomas, uterine leiomyomas, and papillary type 2 renal cancer, which is resistant to current radiotherapy, chemotherapy, and immunotherapy [109]. Here, FH is linked to renal cell adenocarcinoma.