A new survival model was built based on five risk-related FRGs (CARS, NCOA4, FANCD2, HMGCR, and SLC7A11), which indicated that high expression of FANCD2, CARS, and SLC7A11 and low expression of HMGCR and NCOA4 are associated with high-risk ccRCC patients. The gene discussed is NCOA4; the disease is nonpapillary renal cell carcinoma.