SOD1 and metabolic dysfunction-associated steatotic liver disease: However, after co-treatment with PPARα siRNA, the ratio of GSH/GSSH and the content of SOD1 and SOD2 decreased, and the activity of ROS, MDA, NOX2, and NOX4 increased, indicating that LNT restored redox balance in NAFLD, at least partly through the PPARα pathway by enhancing cellular antioxidant activity and improving the ability of cells to scavenge ROS.