BCL2 and breast carcinoma: An in-depth study of the effect of rosmarinic acid on breast cancer cells, MDA-MB-231, by Messeha et al., elucidated that it had a concentration-dependent cytotoxic and antiproliferative effect, causing increased expression of the Karakiri gene, tumor necrosis factor receptor superfamily 25, and BCL-2 interacting protein to be expressed [46].