PTPN1 and obesity due to melanocortin 4 receptor deficiency: Ha et al., 2020, isolated the farnesylated 2-arylbenzofuran compound from M. alba extract which exerts an anti-obesity effect and is a potent inhibitor of the intracellular protein tyrosine phosphatase 1B (PTP1B), which plays a critical role in the insulin receptor signaling pathway [149].