Malfunctions in protein tyrosine phosphatase (PTP) activity are linked to various diseases, ranging from cancer to neurological disorders and diabetes, such as CD45, SHP1, TCPTP, PTP1B and LAR linked to cancer, CD45, SHP1 and LAR also linked to neurological diseases, and PTP1B and LAR also linked to diabetes, etc. [9]. Here, PTPN2 is linked to diabetes mellitus.