Figure 2 shows network plots of the overall populations based on the interconnection of three treatments (I+C, I, and C groups). Moreover, we categorized the three treatment regimens into five subgroups according to different types of ICIs: chemotherapy, PD-1 monotherapy, PD-1 plus chemotherapy, PD-L1 monotherapy, and PD-L1 plus chemotherapy. Finally, we performed a comparison of the risk of IRP between the I+C group and the I group in different cancer populations. Network plots of subgroup analysis are presented in Figures S1 and S2. Here, CD274 is linked to cancer.