Likewise, Zhou et al. found that miR-195 was associated with LNM+ status (p = 0.009), an advanced clinical stage (p = 0.011), and greater cervical stroma involvement (p = 0.03) in patients with CC due to an association with Smad3 protein regulation, which is related to the migration and proliferation of malignant cells in CC as well as in other cancers such as esophageal and prostate cancer [39]. Here, SMAD3 is linked to cancer.