Elevated levels of cytokines such as tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) and transforming growth factor-β1 (TGF-β1) have been found in patients suffering from non-healing leg ulcers as compared to healing ulcers [27,28]. The gene discussed is IL6; the disease is ulcer disease.