SATB2 is not a reliable diagnostic marker to differentiate OSJ from BFOLs of the jaw; however, it could serve as a valuable diagnostic marker in differentiating the small-cell variant of OSJ from Ewing sarcoma of the jaw, while MDM2 may be a useful diagnostic marker in differentiating OSJ from BFOLs of the jaw, especially in the setting of an LGOS or high-grade transformed OS. The gene discussed is SATB2; the disease is Ewing sarcoma.