CD8A and hepatocellular carcinoma: Immunology has been shown to play a significant role in malignancy development.[3] Changes in the immune system have been investigated in HCC for many years.[3] In previous studies, tumor-infiltrating leukocytes (TILs), especially those infiltrating CD3+ and CD8+ cells, have been extensively reported as predictors for survival in numerous human solid malignant tumors.[4,5] Moreover, the predictabilities of these infiltrating leukocytes are suggested to be better than that of conventional clinical staging systems.[6]