CEACAM8 and hepatocellular carcinoma: In our previous study on a western HCC cohort, we noticed that intratumoral CD3+, CD8+, CD20+, and CD66b+ cells were present predominantly around the intratumoral microvessels.[14] We used perivascular regions to capture the hotspots for further survival analysis and validated the prognostic significance.[14] However, it was too weak to prove a relationship between immune cell infiltration and neovascularization, which we were unable to quantify.