Consistent with our data, 2 previous studies have suggested that high expression of RANBP17 is associated with a favorable prognosis for glioma.[12,30] Gao et al[31] found that ISG20 expression increased with the increase of glioma malignancy, and high ISG20 expression predicted a poor prognosis. The gene discussed is RANBP17; the disease is central nervous system cancer.