A previous study showed that RPL31 was overexpressed in prostate cancer tissues, and silencing RPL31 inhibited tumor cell growth and cycle progression, which was due to its regulation of the P53 pathway.[27] NSUN5 is an RNA methylation transferase, which acts as a tumor suppressor in glioma, but NSUN5 expression is down-regulated due to CpG island hypermethylation of the promoter. The gene discussed is NSUN5; the disease is central nervous system cancer.