It contains various bioactive components, including polysaccharides, triterpenoids, and steroids, and may have antitumor,[63] antioxidant,[64] anti-diabetes,[65] and immunomodulatory effects.[66] MAK also regulates the intestinal biological barrier function by modulating intestinal microbiota and decreasing intestinal permeability.[67,68] Nagai et al[28] (2017) investigated the preventive effects of MAK via immunological function and the polysaccharides from MAK on indomethacin-induced ileitis in mice. The gene discussed is MAK; the disease is Crohn ileitis.