The IFG subjects always have high hepatic insulin resistance with almost normal values in skeletal muscle, while high insulin resistance in skeletal muscle with only modest changes in liver insulin sensitivity is commonly in IGT subjects.[3] The incidence of prediabetes is rising as the prevalence of obesity increases globally.[7] So, in this trial, we will select not only the common indicators of prediabetes, such as FBG, 2hPBG, and HbA1c, but also the indicators associated with obesity, like weight, BMI, WC, WHR, WHtR, and blood lipid level. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.