PVT1 encodes multiple miRNAs (miR-1204, miR-1205, miR1206, miR1207-5p, miR-1207-3p, miR-1208,[3] miR-152,[4,5] and miR-186[6]) and has been reported to exhibit oncogenic properties.[3–5,7–9] Polymorphisms of PVT1 have been shown to affect familial predisposition by acting as a genetic risk factor in lymphoma.[10] The accumulation of PVT1 has been reported in esophageal,[11] gastric,[5,6,12–18] colorectal,[19] lung,[20] ovarian and breast cancer,[21] lymphoma,[10,22–24] prostate[25] and pancreatic[26] cancer, and hepatocellular carcinoma.[27]. The gene discussed is PVT1; the disease is cancer.