Modern pharmacological studies have found that Shenkang injection can act by regulating the transforming growth factor-β1/Smad3 protein[10] and mitogen-activated protein kinase, which inhibits renal fibrosis and oxidative stress response,[11] has anti-inflammatory,[12] anti-renal fibrosis,[13,14] and improves coagulation function.[15] Traditional Chinese medicine has significant advantages in improving patient symptoms and renal function,[16,17] and has few adverse reactions. Here, SMAD3 is linked to renal fibrosis.