It is not conclusive yet if TRIM21 plays a pro-oncogenic role or a suppressive role during tumorigenesis; some studies show that TRIM21 is upregulated in a broad spectrum of cancers and promotes the proliferation of breast cancer cell lines (31), and it is upregulated in gliomas and negatively correlated with the prognosis of glioma patients(32). The gene discussed is TRIM21; the disease is cancer.