SLC5A2 and fatty liver disease: Currently, there have been some reports that not only CANA but also other SGLT2 inhibitors increase AMPK phosphorylation [48]; dapagliflozin increased AMPK phosphorylation in myofibroblasts and in high glucose-treated HK-2 cells [49,50], while empagliflozin increased AMPK phosphorylation in myocardial infarction hearts [51] and improved hepatic steatosis by increasing AMPK phosphorylation [52].