Considering that diabetes is often associated with increased risk of sarcopenia, leading to physical inactivity, and metabolic disorders especially in older patients [59], and that diabetes is also known to reduce slow muscle mass and function compared with fast muscle [60], further studies with diabetic mice of various etiologies are required to elucidate the differential effect of SGLT2 inhibition on slow and fast muscles in impaired glucose metabolism. The gene discussed is SLC5A2; the disease is diabetes mellitus.