SLC5A2 and metabolic disease: Considering that diabetes is often associated with increased risk of sarcopenia, leading to physical inactivity, and metabolic disorders especially in older patients [59], and that diabetes is also known to reduce slow muscle mass and function compared with fast muscle [60], further studies with diabetic mice of various etiologies are required to elucidate the differential effect of SGLT2 inhibition on slow and fast muscles in impaired glucose metabolism.