CTNNB1 and hemoglobin measurement: The latter closely resemblespediatric HCC and provides a significant diagnostic challenge at microscopy.5 To differentiate macrotrabecular HB from pediatric HCC or HCN-NOS, closeattention is paid to the staining pattern of beta catenin: macrotrabecular HBexhibits nuclear staining in line with other classic HB subtypes, pediatric HCCmeanwhile shows membranous staining, and often has thicker trabeculae.5,37Macrotrabecular change can be present focally in other subtypes, in which casethe tumor is classified according to its dominant portion.12