CTNNB1 and hepatocellular carcinoma: Beta-catenin is generally less intense in a nuclear distributionin pediatric HCC when compared with HB, however, a rarer subset is strongly andproblematically positive.5,19 The balance is tippedtowards HB in the presence of glutamine synthetase and cyclin D1 positivity, andcertain genetic markers are more commonly encountered, such as chromosome 1pabnormalities and trisomy of chromosomes 2, 20, and 8.5,19,25,27 However, as withimmunohistochemical staining, this distinction is not definitive, and the samegenetic markers are highlighted in up to 40% of pediatric HCC.5