CTNNB1 and hemoglobin measurement: Given the explicitimplication of Wnt/beta-catenin signaling in HB development, studies haveattempted to evaluate this pathway as a potential therapeutic target.11 Activation of Wnt/beta-catenin signaling regulates hallmarks of tumorprogression such as differentiation, metastases and invasive potential.Therefore, suppression of this system can potentially attenuate the progressionand development of HB.11,30Table 2 details theimmunohistochemical markers expressed in the single subtypes of HB.