The results showed that the expression of rSSRP1 R54A dramatically attenuated pyruvate‐enhanced tumor cell viability after etoposide treatment (Figure 5B and Figure S5B, Supporting Information), which confirms that the association of pyruvate with SSRP1 is also required for pyruvate supplementation‐enhanced tumor cell survival upon DNA damage. This evidence concerns the gene SSRP1 and neoplasm.