IF staining with anti‐γH2AX or anti‐MDC1 antibody showed that tumor cells rescued with rPKM2 S222A had much less γH2AX and MDC1 foci than the cells rescued with rPKM2 WT (Figure 7C and Figure S7E, Supporting Information) after etoposide treatment. Here, MDC1 is linked to neoplasm.