Notably, it has also been demonstrated that moderate DNA damage induced by low dose of etoposide promotes the metabolism of phosphate pentose pathway by increasing PKM2 Y105 phosphorylation, which favors the survival of tumor cells.[41] In our study, however, we did not detect the phosphorylation of Y105 in our mass spectrometry experiment, suggesting that Y105 is not abundantly phosphorylated in our context. This evidence concerns the gene PKM and neoplasm.