However, recently, rapidly accumulating evidence indicates that far beyond its metabolic functions, PKM2 performs multiple nonmetabolic functions, including protein kinase and transcriptional coactivator, to regulate tumor cell proliferation, survival, and migration.[11, 16, 37, 38] For example, under oxidative stress, PKM2 is translocated to mitochondria and phosphorylates antiapoptotic protein Bcl2 to prevent its proteasome‐mediated degradation, thereby inhibiting oxidative stress‐induced tumor cell apoptosis.[39] More recently, Sizemore et al. Here, BCL2 is linked to neoplasm.