Here, we performed causal mediation analysis using a simulation‐based, regression‐standardization mediation analysis approach20, 21, 22 that permitted us to take the dependencies between biomarkers into account and to quantify the so‐called “interventional indirect (mediating) effects” of CRP/leptin, fasting insulin, and estradiol in explaining the effect of adiposity on ER‐positive breast, endometrial, and colorectal cancers in postmenopausal women. This evidence concerns the gene CRP and colorectal cancer.