In the UK Biobank cohort, a sequential causal mediation analysis approach was used to explain the effect of adiposity on colorectal cancer risk in postmenopausal women through CRP, glycated hemoglobin (HbA1c, used as a correlate of insulin resistance), and sex hormone‐binding globulin (SHBG) and testosterone.53 This evidence concerns the gene SHBG and colorectal cancer.