For colorectal cancer, the point estimate suggested negligible indirect effects through leptin and CRP (RR 1.04; 95%CI, 0.61–1.72) and estradiol (RR 1.02; 95%CI, 0.83–1.17), with high uncertainty around the estimated effects, but there was a positive indirect effect through fasting insulin (RR 1.36; 95%CI, 1.00–1.88) The RR for direct effect was 1.16 (95%CI, 0.58–2.43) (Table 5). The gene discussed is INS; the disease is colorectal cancer.