Of the total waist circumference–colorectal cancer association (RR for waist circumference >88 vs. ≤80 cm, 1.27; 95%CI, 1.07–1.50), there was evidence for a small mediating effect through CRP (RR 1.08; 95%CI, 0.99–1.17), but not for HbA1c (RR 1.00; 95%CI, 0.98–1.02) or SHBG and testosterone (RR 1.00; 95%CI, 0.92–1.09). This evidence concerns the gene SHBG and colorectal cancer.