Our study found that curzerene‐induced inhibition of GSTA4 expression can significantly induce tumor apoptosis by upregulating the level of 4‐HNE and reducing the level of reduced GSH, indicating that the high expression of GSTA4 enhances the ability of glioma to resist oxidative stress injury and that GSTA4 plays an important role in the maintenance of tumor survival. Here, GSTA4 is linked to neoplasm.