Previous studies have shown that the ALDH2‐rs671 AA and ADH1B‐rs1229984 AA and AG genotypes were associated with lower oesophageal cancer risk compared to the GG genotype,11, 12 and that ALDH2‐rs671 genotype may modify the relationship between alcohol intake and oesophageal cancer risk.12, 13, 14. This evidence concerns the gene ALDH2 and carcinoma of esophagus.