In the present prospective study, in addition to the significant ALDH2‐rs671‐alcohol interactions on head and neck cancer and oesophageal cancer which supported findings from previous studies,12, 13, 14, 20, 33 there was also suggestive evidence of an ALDH2‐rs671‐alcohol interaction on lung cancer risk, which was concordant with a previous Japanese case‐control study (505 cases)36 and our previous report of a stronger dose‐response association of alcohol with lung cancer among male drinkers reporting the alcohol flushing response.5 Here, ALDH2 is linked to head and neck cancer.