Compared to ALDH2‐rs671 GG genotype, AG genotype was associated with significantly higher risks of IARC alcohol‐related cancers (1.30 [1.11‐1.52]) and oesophageal cancer (2.07 [1.58‐2.71]) in male ever‐regular drinkers but not in never‐regular drinkers. This evidence concerns the gene ALDH2 and carcinoma of esophagus.