GLUD1 plays a pro-survival role in cancers such as gliomas by driving anaplerosis, lipid biosynthesis, cell proliferation, and metastasis [107,108], with overexpression of GLUD1 and GLUD2 being particularly important in mutant IDH1-driven cancers to compensate production of αKG required for energy and metabolite production and lipid biosynthesis [109]. This evidence concerns the gene IDH1 and central nervous system cancer.