Recently, Bello et al. [68] proposed that the interactions between the adhesion proteins FAK, paxillin and PI3K may be relevant in the aggressiveness of AM compared to AOT, based on the observation that FAK expression was stronger in AM compared to AOT, and that one case of peripheral AM with strong expression of the three proteins had a history of two recurrences. This evidence concerns the gene PTK2 and acute myeloblastic leukemia with maturation.