In a similar way, other somatic mutations have been reported in ameloblastoma, mainly affecting: SMO [6, 8, 10, 14], other MAPK pathway-related genes such as KRAS, NRAS, HRAS, FGFR2 [6, 8, 10, 12, 14, 16] and in a lower frequency, PTEN [10, 12, 34] and CTNNB1 [8, 10, 12, 13, 16, 34, 42, 44, 45] among others. Here, SMO is linked to ameloblastoma.