Unlike wild-type 4E, the expression of the phospho-mutant (S209A) in MEF increases resistance to cellular transformation, and non-phosphorylatable eIF4E mutant mice (eIF4ES209A) and MNK1/2-deficient mice are resistant to tumor progression despite a genetic background that would otherwise promote invasive cancers [23, 24]. Here, EIF4E is linked to neoplasm.