Moreover, DNA hypermethylation triggered by DNMT overexpression in AME could induce the silencing of important regulatory and tumor suppressor genes, such as cell cycle genes [22–24], apoptosis [25], matrix metalloproteinases [26], LINE-1 [27], and the mismatch repair genes MSH2 and MSH6 [28]. This evidence concerns the gene MSH6 and neoplasm.