This finding is in accordance with what has been previously observed in other human neoplasms, such as oral cancer [42], esophageal squamous cell carcinoma [43], melanoma [44], diffuse large B-cell lymphomas [45], hepatocellular cancer [46], and gastric cancer [47], showing DNMT1 and DNMT3B overexpression associated with poor prognosis. Here, DNMT3B is linked to melanoma.