PIK3CA and ameloblastoma: Aside from the SMO mutations, APC mutations have been detected in 3/6 ameloblastomas [78], and CTNNB1, PIK3CA, SMARCB1, PTEN, CDKN2A mutations have been reported in a few cases and tend to occur in a non-mutually exclusive manner with BRAF p.V600E mutation and with each other [52, 54, 55].