We have subjected mixed odontogenic tumor samples to laser capture microdissection before molecular testing in an attempt to avoid epithelial-mesenchymal cross-contamination and using allele-specific quantitative PCR, a high sensitivity mutation detection assay, we detected the BRAF p.V600E mutation in the mesenchymal component of all mutation-positive mixed odontogenic tumors (9/9) [13]. The gene discussed is BRAF; the disease is odontogenic neoplasm.