The detection of TP53 mutation in the malignant area of a tumor arising from preexisting ameloblastoma [80] and observation of TP53 and CTNNB1 in a BRAF p.V600E wild-type ameloblastic carcinoma [72] suggest that mutations in these genes might play a role in the malignant transformation process of ameloblastomas. The gene discussed is TP53; the disease is ameloblastoma.