TNFα (p = 0.0038), MCP1 (CCL2) (p = 0.0493), IL-1β (P = 0.0043), and IL-8 (p = 0.0035) were increased in OSCC compared to control only while MIP1β (CCL4) (p < 0.0365) was increased in OSCC patients compared to periodontal disease patients. This evidence concerns the gene IL1B and periodontal disorder.