There was a significant increase in GMCSF (OSCC > Control p = 0.0057, OSCC > perio, p = 0.0080), IL-6 (OSCC > control p = 0.0001; OSCC > perio p = 0.0015), Rantes/CCL5 (OSCC > control p = 0.0079; OSCC > perio p = 0.0227) and MIP1α (CCL3) (OSCC > control p = 0.0034; OSCC > perio p = 0.0218) in OSCC patients compared to control and periodontal disease patients. The gene discussed is CCL3; the disease is periodontal disorder.