We also calculated the total number of identified cells (CD66b+, CD4+, CD8+, CD56+, CD68+, Siglec8+, CD138+) and OSCC patients showed significantly more cells (55,966 ± 22,151) compared to periodontal disease (32,550 ± 11,816) and control patients (6,355 ± 4,733). The gene discussed is SIGLEC8; the disease is periodontal disorder.