EGF and cancer: However, as malignant epithelial cells in OSCC cannot repair the barrier, the M2 and M-MDSC continue to receive TLR- and cytokine-mediated stimulation, produce IL-6, IL-10, TGF-beta, and other factors that suppress antitumor responses, and also support cancer cells in other ways, such as secrete epidermal growth factor (EGF) and VEGFA [170, 176–178].